Investigating ways to prevent Alzheimer's disease in families with a genetic risk.
Alzheimer's Prevention Initiative ADAD Colombia Trial Program
This study is looking for people from a big Colombian family who have a genetic mutation that causes early Alzheimer's disease to see if new treatments can help prevent symptoms from starting, while also making sure everyone feels supported and involved throughout the process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Banner Health NIH-funded |
| Lab location | 1 site (Phoenix, United States) |
| Project ID | NIH-10855439 on NIH RePORTER |
What this research studies
This research focuses on individuals from a large Colombian family with a genetic mutation that leads to early-onset Alzheimer's disease. It aims to evaluate the effectiveness of experimental treatments designed to prevent the onset of Alzheimer's symptoms in those at high risk. Participants will undergo various assessments, including brain imaging and biomarker analysis, to monitor the impact of the treatment over several years. The study emphasizes ethical considerations and community involvement, ensuring that participants are valued and supported throughout the process.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals from families with the presenilin 1 (PSEN1) E280A mutation who are at high risk of developing Alzheimer's disease.
Not a fit: Patients without a genetic predisposition to early-onset Alzheimer's disease or those with late-onset Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective prevention strategies for Alzheimer's disease in genetically predisposed individuals.
How similar studies have performed: Previous research has shown success with similar approaches in treating Alzheimer's disease, particularly with antibody treatments that target amyloid plaques.
Where this research is happening
Phoenix, United States
- Banner Health — Phoenix, United States (Active)
Researchers
- Principal investigator: Alexander, Robert C — Banner Health
- Study coordinator: Alexander, Robert C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.