Investigating ways to inhibit the KRAS oncogene in cancer treatment
Cellular mechanisms and therapeutic possibilities of inhibiting oncogenic KRAS
This study is looking at new ways to block a gene called KRAS that often causes cancer, with the hope of finding better treatments for patients with KRAS-related tumors.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hunter College NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10686125 on NIH RePORTER |
What this research studies
This research focuses on understanding how to inhibit the KRAS oncogene, which is frequently mutated in various cancers. The team is exploring new pharmacological agents that can bind to KRAS and prevent its harmful effects, potentially leading to cancer regression. By studying the cellular consequences of KRAS loss and the mechanisms behind these inhibitors, the research aims to identify effective combination therapies for patients with KRAS-driven tumors. This work could provide insights into targeted treatments for some of the most challenging cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers that have mutations in the KRAS gene.
Not a fit: Patients with cancers not driven by KRAS mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively treat cancers driven by KRAS mutations.
How similar studies have performed: Other research has shown promise in targeting KRAS mutations, but this specific approach is novel and untested.
Where this research is happening
New York, United States
- Hunter College — New York, United States (Active)
Researchers
- Principal investigator: Wolfe, Andrew L — Hunter College
- Study coordinator: Wolfe, Andrew L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.