Investigating ways to improve treatment adherence for opioid use disorder
Testing the Effects of Contingency Management and Behavioral Economics on Buprenorphine-Naloxone Treatment Adherence Using a Sequential Multiple Assignment Randomized Trial (SMART) Design
['FUNDING_OTHER'] · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · NIH-10474683
This study is looking to help people with opioid use disorder stick to their Medication Assisted Treatment by trying out two different support methods, so if you're starting treatment with buprenorphine-naloxone, your feedback could help make these programs better for everyone!
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TENNESSEE HEALTH SCI CTR (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-10474683 on ClinicalTrials.gov |
What this research studies
This research focuses on enhancing adherence to Medication Assisted Treatment (MAT) for individuals with opioid use disorder by testing two behavioral economics interventions. The study will first gather insights from current patients using buprenorphine-naloxone to identify factors affecting their treatment adherence. Based on this data, the researchers will adapt an existing intervention that combines motivational interviewing with substance-free activities, and compare it to a contingency management approach. Both interventions will be evaluated for their effectiveness and acceptability among new patients starting MAT.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals initiating treatment with buprenorphine-naloxone for opioid use disorder.
Not a fit: Patients not seeking treatment for opioid use disorder or those not eligible for buprenorphine-naloxone therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved adherence to opioid use disorder treatments, potentially reducing relapse rates and enhancing recovery outcomes.
How similar studies have performed: Previous research has shown promise in using behavioral economics to improve treatment adherence, indicating that this approach may be effective.
Where this research is happening
MEMPHIS, UNITED STATES
- UNIVERSITY OF TENNESSEE HEALTH SCI CTR — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DEREFINKO, KAREN J — UNIVERSITY OF TENNESSEE HEALTH SCI CTR
- Study coordinator: DEREFINKO, KAREN J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.