Investigating ways to improve cancer therapy by targeting specific pathways in lung cancer.
BLRD Merit Review Research Career Scientist (RCS) Award (IK6)
This study is looking at how lung cancer grows and how the immune system responds, with the hope of finding better treatments by focusing on a specific pathway in the body; if you're a lung cancer patient, the findings could help improve your treatment options.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10948103 on NIH RePORTER |
What this research studies
This research focuses on understanding the molecular mechanisms behind tumor growth and immune response in lung cancer. It aims to explore how targeting specific signaling pathways, particularly mTOR, can help overcome resistance to current cancer treatments. The approach involves studying the effects of inhibiting mTORC2, a component of the mTOR signaling pathway, and assessing the potential of low-dose mTORC1 inhibitors to improve blood vessel function and enhance anti-tumor immunity. Patients may benefit from insights that could lead to more effective therapies for lung cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with lung cancer, particularly those with subtypes that are resistant to current targeted therapies.
Not a fit: Patients with non-lung cancers or those whose lung cancer is already effectively managed by existing treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for lung cancer patients who do not respond to existing therapies.
How similar studies have performed: Previous research has shown promise in targeting mTOR pathways for cancer treatment, indicating that this approach may lead to significant advancements.
Where this research is happening
Nashville, United States
- Veterans Health Administration — Nashville, United States (Active)
Researchers
- Principal investigator: Chen, Jin — Veterans Health Administration
- Study coordinator: Chen, Jin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.