Investigating ways to enhance glucose uptake in the muscles of older adults
Non-canonical Mechanisms and Unconventional Approaches to Activate AMPK and Glucose Uptake in the Skeletal Muscle of Older Rats
This study is looking at how certain methods, like eating less and using a new medication, can help older adults' muscles use sugar better, which is important for staying healthy and managing insulin resistance as we age.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10783555 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain mechanisms can improve glucose uptake in the skeletal muscles of older rats, which is crucial for managing insulin resistance and age-related diseases. The study will explore the effects of caloric restriction and a new AMPK activator called aldometanib on muscle function and glucose metabolism. By examining these factors, the research aims to uncover potential strategies for promoting healthy aging and improving insulin sensitivity in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who may be experiencing insulin resistance or related age-related health issues.
Not a fit: Patients under the age of 65 or those without insulin resistance or related metabolic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance muscle glucose uptake and improve metabolic health in older adults.
How similar studies have performed: Previous research has shown promising results in enhancing glucose uptake through caloric restriction and AMPK activation, indicating that this approach may be effective.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Cartee, Gregory D. — University of Michigan at Ann Arbor
- Study coordinator: Cartee, Gregory D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.