Investigating ways to delay Alzheimer's Disease using genetic and drug interventions in fruit flies and mice.
The effect of life span modifying interventions on Alzheimer's Disease in Drosophila and Mice.
This study is looking at new ways to slow down Alzheimer's disease by testing different treatments on fruit flies and mice, which could help us find better options for people with the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-10820565 on NIH RePORTER |
What this research studies
This research aims to explore genetic and pharmacological methods to slow down the onset and progression of Alzheimer's Disease (AD). By studying both fruit flies and mice, the researchers will test various interventions that may enhance cellular and mitochondrial functions, potentially leading to healthier aging and reduced neurodegeneration. The approach focuses on understanding how age-related changes affect the brain and finding ways to counteract these effects through innovative treatments. Patients may benefit from insights gained that could lead to new therapies for AD.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals at risk for Alzheimer's Disease or those experiencing early symptoms of cognitive decline.
Not a fit: Patients with advanced Alzheimer's Disease or other forms of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly delay the onset of Alzheimer's Disease and improve the quality of life for patients.
How similar studies have performed: Previous research has shown promise in using genetic and pharmacological approaches to extend lifespan and healthspan in model organisms, suggesting potential for success in this area.
Where this research is happening
Providence, United States
- Brown University — Providence, United States (Active)
Researchers
- Principal investigator: Helfand, Stephen L — Brown University
- Study coordinator: Helfand, Stephen L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.