Investigating ways to delay aging and age-related diseases using genetic, drug, and diet interventions.
Official title: Hierarchy and intersection of hallmarks of aging using genetic, pharmacologic, and dietary life span extending interventions in flies and mice.
Funded at Brown University · NIH-10901046 · Data updated 2026-11-12
This study is looking at how changes in genes, medications, and diet might help slow down age-related diseases like Alzheimer's, using experiments on flies and mice to find new ways to improve health as we get older, which could eventually help people like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $395,796 |
| NIH project number | 1R56AG082810-01 |
| Project ID | NIH-10901046 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are older adults or individuals at risk for age-related diseases, particularly those with a family history of Alzheimer's or similar conditions.
✕Less likely to help
Patients who are not experiencing age-related diseases or are significantly younger may not receive direct benefits from this research.
What this research studies
This research aims to explore how genetic, pharmacologic, and dietary interventions can help delay the onset and progression of age-related diseases, such as Alzheimer's. By studying the interconnectedness of aging hallmarks, the researchers will identify which factors initiate aging processes and which are the effects of these processes. The study will involve experiments on flies and mice to test these interventions and their impact on health and longevity. Patients may benefit from insights gained that could lead to new therapies for age-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve health and longevity for aging individuals.
How similar studies have gone: Other research has shown promise in using genetic and dietary interventions to influence aging, suggesting that this approach could yield significant insights.
Where this research is happening
-
Brown University
Providence, United States Active
Researchers
- Principal investigator: Helfand, Stephen L — Brown University
- Study coordinator: Helfand, Stephen L
Related research
Other NIH-funded projects on the same topics.
-
Aging Well with HIV: Alcohol, Risk Reduction, and Education Center (AWAR3E)
A center at Yale is exploring how aging with HIV interacts with alcohol use to create inflammation and frailty, with the goal of finding biomarkers and potential treatments.
-
Cognitive SuperAging: Exploring why some octogenarians stay sharp in memory
This NIH grant studies why a small group of people aged 80+ keep memory skills as good as much younger people, hoping to understand how to protect memory as we age.
-
Biological aging across the lifespan through a national high school-to-adult study
This grant uses a long-running national study of students and adults to collect saliva biomarkers of aging, alongside surveys, to understand how aging markers relate to health and life experiences.
-
Understanding how aging and Alzheimer’s affect how people make tough choices
This NIH grant studies how aging and Alzheimer’s risk change how people decide between immediate and delayed rewards and risky options, with the goal of helping older adults stay financially and healthwise safer.
-
Understanding how brain resilience and multiple brain pathologies influence aging and Alzheimer's disease
A long-term study follows older adults to learn how resilience to brain changes helps reduce dementia risk and what biological factors are linked to better cognitive aging.
-
National Neighborhood Data Archive helps researchers study aging health in U.S. neighborhoods
A nationwide data resource will help researchers understand how where people live affects health and aging, with a focus on respiratory illnesses in older adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.