Investigating ways to correct abnormal signaling in colon cancer cells
Targeting plasma membrane spatial dynamics to suppress aberrant Wnt signaling
['FUNDING_R01'] · TEXAS A&M AGRILIFE RESEARCH · NIH-10829849
This study is looking at how certain changes in colon cells can lead to colorectal cancer and is testing if natural foods can help fix these changes to create safer and more effective treatments for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEXAS A&M AGRILIFE RESEARCH (nih funded) |
| Locations | 1 site (College Station, UNITED STATES) |
| Trial ID | NIH-10829849 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how the Wnt signaling pathway, which is often disrupted in colorectal cancer, can be targeted for therapeutic purposes. The approach involves studying the spatial dynamics of the plasma membrane in colon cells, particularly how mutations in a tumor suppressor gene affect cell signaling. By exploring non-toxic dietary bioactives that can restore normal membrane function, the research aims to develop new treatment strategies that minimize side effects and improve targeting of cancer cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with colorectal cancer, particularly those with mutations in the APC gene.
Not a fit: Patients with other types of cancer not related to Wnt signaling or those without colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatments for colorectal cancer by correcting the underlying signaling issues.
How similar studies have performed: Previous research has shown promise in targeting similar pathways in cancer treatment, indicating potential for success in this novel approach.
Where this research is happening
College Station, UNITED STATES
- TEXAS A&M AGRILIFE RESEARCH — College Station, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHAPKIN, ROBERT STEPHEN — TEXAS A&M AGRILIFE RESEARCH
- Study coordinator: CHAPKIN, ROBERT STEPHEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer