Investigating vascular side effects of anti-amyloid treatments for Alzheimer's disease
Official title: Understanding and Mitigating Vascular Side-Effects Associated with Anti-Amyloid Immunotherapy
Funded at Brigham and Women's Hospital · NIH-11081649 · Data updated 2026-11-12
This study is looking at how new Alzheimer's treatments might affect blood vessels in the brain and cause side effects, especially in people with certain genes, so we can find ways to make these therapies safer for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $783,917 |
| NIH project number | 5R01NS136122-02 |
| Project ID | NIH-11081649 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with early-stage Alzheimer's disease, particularly those who are APOE ε4 allele carriers.
✕Less likely to help
Patients with Alzheimer's disease who do not carry the APOE ε4 allele or those in advanced stages of the disease may not benefit from this research.
What this research studies
This research focuses on understanding the vascular side effects associated with new anti-amyloid immunotherapies for Alzheimer's disease, specifically the risks of Amyloid Related Imaging Abnormalities (ARIA). It aims to identify how these treatments interact with vascular amyloid and the factors that increase the risk of ARIA, particularly in patients with certain genetic predispositions. By analyzing patient responses and the underlying mechanisms of these side effects, the research seeks to develop strategies to mitigate these risks, enhancing the safety of these promising therapies.
Why it matters
Potential benefit: If successful, this research could lead to safer anti-amyloid treatments for Alzheimer's patients, reducing the risk of serious vascular side effects.
How similar studies have gone: Other research has shown that understanding the mechanisms of ARIA can lead to improved patient outcomes, indicating that this approach has potential for success.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Lemere, Cynthia a — Brigham and Women's Hospital
- Study coordinator: Lemere, Cynthia a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.