Investigating variations in the AMH signaling pathway related to PCOS

Who could benefit from this research

What this research studies

This research focuses on Polycystic Ovary Syndrome (PCOS), a common condition affecting reproductive-age women that can lead to infertility and other health issues. The study aims to identify genetic variations in the anti-Müllerian hormone (AMH) gene and its receptor, which may contribute to the development and severity of PCOS. By conducting whole genome sequencing, researchers will analyze the impact of these genetic variants on hormone signaling and their potential role as biomarkers for PCOS. This could lead to better understanding and management of the condition for affected individuals.

Why it matters

Where this research is happening

• Northwestern University at Chicago
  Chicago, United States Active

Researchers

• Principal investigator: Urbanek, Margrit — Northwestern University at Chicago
• Study coordinator: Urbanek, Margrit

Related research

Other NIH-funded projects on the same topics.

• Genetically Validated PCOS Subtypes for Better Diagnosis and Risk Stratification

  Aimed at women with polycystic ovary syndrome (PCOS), this project uses genetic data and patient characteristics to define distinct PCOS subtypes and improve how we diagnose and estimate risk.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11623556

• Understanding how PCOS develops during adolescence

  This grant looks at how polycystic ovary syndrome begins in teenagers and what early signs help doctors diagnose it accurately.

  NIH research Cornell University · Ithaca, United States · NIH-11378637

• Genetically guided PCOS subtypes to improve diagnosis and risk stratification

  Aims to use genetic patterns to identify PCOS subtypes so doctors can diagnose it more precisely and tailor risk predictions for each patient.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11298558

• Using inositol to improve reproductive and metabolic health in women with PCOS

  This study is looking at how taking inositol might help women with polycystic ovary syndrome (PCOS) by checking its effects on hormone levels and overall health over three months.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11167238

• Understanding how dopamine affects reproductive hormone release in women with PCOS

  This study is looking at how certain brain cells that control hormone release can help women with reproductive issues like PCOS and hypothalamic amenorrhea, and it’s testing if a compound that affects these cells can help balance hormone levels.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11160997

• Investigating how genetic variations in gonadotropin pathways affect PCOS

  This study is looking at how our genes might play a role in Polycystic Ovary Syndrome (PCOS) to help find better treatments for women dealing with this condition.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-11069504

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.