Investigating urinary tract dysfunction and its molecular mechanisms
Bedside to bench resources for lower urinary tract research
This study is looking at how bladder problems in older men with an enlarged prostate can be better understood by examining changes in their cells, and it hopes to find new ways to help manage these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11112321 on NIH RePORTER |
What this research studies
This research focuses on understanding lower urinary tract dysfunction (LUTD), particularly in elderly men suffering from benign prostatic hyperplasia (BPH). It aims to identify specific molecular changes associated with LUTD by producing multi-omic data from human specimens and linking this data to a comprehensive tissue repository. Additionally, the study will develop new mouse models to explore the role of specific cell types in bladder and prostate function, which could lead to better therapeutic targets for managing LUTD.
Who could benefit from this research
Good fit: Ideal candidates for this research are elderly men experiencing symptoms of lower urinary tract dysfunction, particularly those with benign prostatic hyperplasia.
Not a fit: Patients with LUTD not related to benign prostatic hyperplasia or those with other unrelated urinary conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients suffering from lower urinary tract dysfunction.
How similar studies have performed: While there has been limited progress in LUTD treatment over the past 40 years, this research approach is novel in its focus on cell type-specific molecular mechanisms.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Strand, Douglas William — Ut Southwestern Medical Center
- Study coordinator: Strand, Douglas William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.