Investigating unique genetic markers in aggressive prostate cancers among African American patients

Who could benefit from this research

What this research studies

This research focuses on understanding how specific genetic variations, particularly in mRNA splicing, contribute to the higher rates of aggressive prostate cancer in African American men. By analyzing prostate cancer samples, the study aims to identify unique splice variants that may serve as biomarkers for more effective treatment and management of the disease. The approach includes validating these genetic markers through advanced techniques like RT-PCR and functional analyses. The ultimate goal is to uncover intrinsic biological differences that could explain disparities in prostate cancer outcomes between African American and European American patients.

Why it matters

Where this research is happening

• University of Maryland Eastern Shore
  Princess Anne, United States Active

Researchers

• Principal investigator: Wang, Bi-Dar — University of Maryland Eastern Shore
• Study coordinator: Wang, Bi-Dar

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.