Investigating tumor biology differences in multiple myeloma among individuals of African ancestry
Official title: Differences in Tumor Biology of Multiple Myeloma in Association with African Ancestry
Funded at Mayo Clinic Rochester · NIH-10931365 · Data updated 2026-11-12
This study is looking at how multiple myeloma affects Black/African American people differently than European Americans, aiming to find out why there are differences in health outcomes and what factors might be involved, so we can improve care for everyone.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 19, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $467,019 |
| NIH project number | 5R37CA272883-02 |
| Project ID | NIH-10931365 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are newly diagnosed African American individuals with multiple myeloma.
✕Less likely to help
Patients of non-African ancestry or those with other types of cancers may not receive direct benefits from this research.
What this research studies
This research focuses on understanding how multiple myeloma, a common blood cancer, affects Black/African American individuals differently compared to European Americans. It aims to explore the genetic variations of tumors and their microenvironments in newly diagnosed patients, with a particular emphasis on those of African ancestry. By analyzing these differences, the study seeks to uncover the reasons behind health disparities in incidence and outcomes for African American patients. The research will involve large-scale comparisons to identify biological, environmental, and healthcare access factors that contribute to these disparities.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies and outcomes for African American patients with multiple myeloma.
How similar studies have gone: Previous research has highlighted significant disparities in cancer outcomes based on ancestry, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Baughn, Linda B — Mayo Clinic Rochester
- Study coordinator: Baughn, Linda B
Related research
Other NIH-funded projects on the same topics.
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Integrative study of multiple myeloma genetics and disease biology
A team at Dana-Farber and partners is pursuing a long-term project to understand the genetic and molecular drivers of multiple myeloma and how treatments interact with disease biology.
-
Comparative Modeling to Prevent, Detect Early, and Treat Multiple Myeloma
A research team will build and compare computer models to understand how multiple myeloma develops, can be detected earlier, and treated more effectively.
-
How LDL Affects Multiple Myeloma: New Pathways to Keep Remission
A new grant is studying how cholesterol from LDL particles fuels multiple myeloma and how this interaction influences the tumor environment and immune response, with goals to help patients stay in remission.
-
Therapy-induced senescence and immune activation in multiple myeloma
A study in people with multiple myeloma will explore how treatment-related senescence in cancer cells may stimulate the immune system and affect cancer return after standard frontline therapy.
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BCMA CAR-T enteritis: understanding immune toxicities in multiple myeloma
A broad study to uncover why some CAR-T cell treatments targeting BCMA cause severe intestinal inflammation in people with multiple myeloma.
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Understanding Drug-Resistant Multiple Myeloma to Stop Relapse
Researchers are studying why some myeloma cells resist treatment and how to create new therapies to prevent relapse.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.