Investigating treatments for severe skin reactions like Stevens-Johnson syndrome.
NATIENS: A Phase III Randomized Double Blinded Study to Determine the Mechanisms and Optimal Management of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
This study is looking for the best ways to treat serious skin conditions called Stevens-Johnson syndrome and toxic epidermal necrolysis by comparing different treatments, and it's for people who are dealing with these conditions to help improve their care.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11146330 on NIH RePORTER |
What this research studies
This research focuses on Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), which are serious skin conditions caused by adverse drug reactions. The study aims to determine the most effective treatments by comparing cyclosporine, etanercept, and supportive care in a randomized, double-blind manner across multiple sites in the U.S. Patients will be monitored for their immune responses and clinical outcomes, providing valuable data to improve management strategies for these conditions. The research also seeks to address gaps in genetic screening and treatment efficacy for diverse populations.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals aged 21 and older who have been diagnosed with Stevens-Johnson syndrome or toxic epidermal necrolysis.
Not a fit: Patients with mild skin reactions or those not diagnosed with SJS or TEN may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols and better outcomes for patients suffering from SJS and TEN.
How similar studies have performed: Previous research has shown promise in identifying effective treatments for SJS and TEN, but this study aims to fill critical gaps in knowledge and treatment efficacy.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Phillips, Elizabeth — Vanderbilt University Medical Center
- Study coordinator: Phillips, Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.