Investigating treatments for post-hemorrhagic hydrocephalus in the brain.
Targeting the Choroid Plexus-Cerebrospinal Fluid System to Treat Post-Hemorrhagic Hydrocephalus
This study is looking at ways to help premature babies with post-hemorrhagic hydrocephalus, a condition caused by bleeding in the brain, by finding better treatments that improve the balance of fluid in their brains and reduce damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11004388 on NIH RePORTER |
What this research studies
This research focuses on understanding and treating post-hemorrhagic hydrocephalus (PHH), a condition that can occur in premature infants due to bleeding in the brain. The study aims to explore how the choroid plexus, which produces cerebrospinal fluid (CSF), and macrophages, which help clear blood from the ventricles, can be manipulated to improve CSF balance and reduce brain damage. By examining the mechanisms of CSF production and removal, the research seeks to identify potential therapeutic targets that could alleviate the symptoms of PHH. Patients may benefit from new treatment strategies developed from this research.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults who have experienced complications from post-hemorrhagic hydrocephalus or related conditions.
Not a fit: Patients who do not have a history of brain hemorrhage or hydrocephalus may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from post-hemorrhagic hydrocephalus, potentially reducing neurological deficits.
How similar studies have performed: Other research has shown promise in targeting cerebrospinal fluid dynamics and macrophage activity for treating similar conditions, indicating a potential for success in this approach.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Lehtinen, Maria — Boston Children's Hospital
- Study coordinator: Lehtinen, Maria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.