Investigating treatments for post-hemorrhagic hydrocephalus in infants
Targeting the Choroid Plexus-Cerebrospinal Fluid System to Treat Post-Hemorrhagic Hydrocephalus
This study is looking at ways to help premature babies with post-hemorrhagic hydrocephalus, a condition caused by bleeding in the brain, by finding better treatments that improve the balance of fluid in their brains and reduce damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11221537 on NIH RePORTER |
What this research studies
This research focuses on understanding and treating post-hemorrhagic hydrocephalus (PHH), a condition that affects premature infants due to bleeding in the brain. The study aims to explore how the choroid plexus, which produces cerebrospinal fluid (CSF), and macrophages, which help clear blood from the ventricles, can be manipulated to improve CSF balance and reduce brain damage. By examining the mechanisms behind CSF production and removal, the research seeks to develop targeted therapies that could alleviate the symptoms of PHH. Patients may benefit from new treatment options that address the underlying causes of this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are premature infants who have experienced intraventricular hemorrhage and are at risk for developing post-hemorrhagic hydrocephalus.
Not a fit: Patients who are older than 21 years or who do not have a history of intraventricular hemorrhage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for infants suffering from post-hemorrhagic hydrocephalus, potentially reducing neurological deficits.
How similar studies have performed: Previous research has shown promise in understanding CSF dynamics and treatments for hydrocephalus, indicating that this approach may lead to meaningful advancements.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Lehtinen, Maria — Boston Children's Hospital
- Study coordinator: Lehtinen, Maria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.