Investigating treatments for persistent smell loss after COVID-19
A randomized controlled trial of smell training and trigeminal nerve stimulation in the treatment of COVID-related persistent smell loss
This study is looking for people who have lost their sense of smell because of COVID-19 to try a new treatment that combines smell training with a special type of nerve stimulation, to see if it helps them recover better than just standard care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-11099886 on NIH RePORTER |
What this research studies
This research explores new treatment options for individuals experiencing ongoing smell loss due to COVID-19. It combines smell training with trigeminal nerve stimulation to enhance recovery from this condition. Participants will engage in a randomized controlled trial, where they will receive either the combined treatment or standard care. The study aims to assess the effectiveness of these interventions in improving not only smell but also related issues such as mood and cognitive function.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have experienced smell loss due to COVID-19 and are struggling with related cognitive or mood impairments.
Not a fit: Patients who have not experienced smell loss or those with smell loss due to causes unrelated to COVID-19 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the quality of life for patients suffering from persistent smell loss and associated symptoms following COVID-19.
How similar studies have performed: Previous research has shown promise in using smell training for similar conditions, but this specific combination of treatments is novel and has not been extensively tested.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Cortese, Bernadette — Medical University of South Carolina
- Study coordinator: Cortese, Bernadette
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.