Investigating treatments for head and neck cancer related to HPV
Targeting replication stress and homologous recombination repair mechanisms in HPV-positive and negative head and neck cancer
This study is looking at how different types of head and neck cancer, especially those related to HPV, respond to new treatments that focus on fixing DNA damage, so we can find out which patients might get the most help from these targeted therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11074577 on NIH RePORTER |
What this research studies
This research focuses on head and neck squamous cell carcinoma (HNSCC), a common and serious cancer that affects many individuals each year. The study aims to understand how HPV-positive and negative HNSCCs respond to treatments that target specific DNA repair mechanisms. By examining the biology of these cancers, researchers hope to identify which patients may benefit from targeted therapies that address their unique tumor characteristics. The approach includes laboratory experiments to test the effectiveness of drugs that inhibit DNA damage repair processes in these cancer types.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with head and neck squamous cell carcinoma, particularly those with HPV-positive or HPV-negative tumors.
Not a fit: Patients with other types of cancers or those without head and neck squamous cell carcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for patients with head and neck cancer.
How similar studies have performed: Previous research has shown promising results in targeting DNA repair mechanisms in various cancers, suggesting potential success for this approach in head and neck cancer.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Osman, Abdullah Ali — University of Tx Md Anderson Can Ctr
- Study coordinator: Osman, Abdullah Ali
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.