Investigating treatments for filarial infections caused by parasitic worms
Slo-1K channels, TRP-2 channels, emodepside and diethylcarbamazine in Filaria
This study is looking at how well certain medications can help treat filariases, like lymphatic filariasis and river blindness, to find better ways to help the millions of people affected by these diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Iowa State University NIH-funded |
| Lab location | 1 site (Ames, United States) |
| Project ID | NIH-10899540 on NIH RePORTER |
What this research studies
This research focuses on filariases, a group of neglected tropical diseases caused by parasitic nematodes transmitted by insects. It aims to improve treatment options for conditions like lymphatic filariasis and river blindness, which affect millions globally. The study explores the effects of existing anthelmintic drugs, particularly diethylcarbamazine, on these parasites and their interactions with host biological pathways. By understanding how these drugs work, the research seeks to enhance their efficacy and develop better treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with filarial infections, particularly those suffering from lymphatic filariasis or river blindness.
Not a fit: Patients with filarial infections who are not responsive to anthelmintic treatments or those with contraindications to diethylcarbamazine may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for debilitating filarial diseases, improving the quality of life for affected patients.
How similar studies have performed: Previous research has shown promise in improving treatment outcomes for filarial infections using similar drug mechanisms, indicating potential for success in this approach.
Where this research is happening
Ames, United States
- Iowa State University — Ames, United States (Active)
Researchers
- Principal investigator: Martin, Richard John — Iowa State University
- Study coordinator: Martin, Richard John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.