Investigating treatments for cirrhosis using statins
USC Cirrhosis Clinical Center
This study is for people with compensated cirrhosis and aims to see how taking statins might help improve their health and reduce complications over time, while also keeping track of their progress through regular check-ups and tests.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10909267 on NIH RePORTER |
What this research studies
This research focuses on patients with compensated cirrhosis, a condition where the liver is damaged but still functions adequately. The study aims to follow a cohort of 2000 patients to monitor changes in their health over time, particularly looking at how statins may help reduce complications like portal hypertension. Patients will undergo regular assessments, including clinical evaluations and laboratory tests, while also contributing biological samples for future studies. The goal is to better understand the progression of cirrhosis and the potential benefits of statin therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with compensated cirrhosis, particularly those exhibiting clinically significant portal hypertension.
Not a fit: Patients with decompensated cirrhosis or those without a diagnosis of cirrhosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with compensated cirrhosis, potentially reducing the risk of severe liver complications.
How similar studies have performed: Preliminary data from other studies suggest that statins may be effective in managing cirrhosis, indicating a promising avenue for further exploration.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Terrault, Norah a. — University of Southern California
- Study coordinator: Terrault, Norah a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.