Investigating treatments for aggressive brain cancer with specific genetic mutations
Vulnerabilities of MMR-deficient glioblastoma
This study is looking for new ways to treat a tough type of brain cancer called glioblastoma, especially in patients whose tumors have specific gene mutations that make them harder to treat, by testing some promising new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10893006 on NIH RePORTER |
What this research studies
This research focuses on glioblastoma, a highly aggressive brain cancer that often resists standard treatments. It specifically examines glioblastomas that have mutations in DNA mismatch repair genes, making them particularly difficult to treat. The study aims to explore novel therapeutic approaches, including the use of calcium channel inhibitors and targeting TGF-β, to find effective treatments for these challenging cases. By utilizing unique tools and methodologies, the research seeks to improve outcomes for patients with MMR-deficient glioblastoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with MMR-deficient glioblastoma who have not responded to standard treatments.
Not a fit: Patients with glioblastoma that does not have MMR deficiencies or those who are not adults may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients with a form of brain cancer that currently has limited effective therapies.
How similar studies have performed: While there have been some successes in treating pediatric MMR-deficient glioblastomas with immunotherapy, adult cases have shown limited responses, making this research both novel and necessary.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Purow, Benjamin W. — University of Virginia
- Study coordinator: Purow, Benjamin W.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.