Investigating timing and movement control in a mouse model of Parkinson's disease
Arousal and Timekeeping in a Mouse Model of Parkinsonism
['FUNDING_R15'] · UTAH STATE UNIVERSITY · NIH-10437525
This study is looking at how Parkinson's Disease affects the way people estimate and keep track of time, which is important for movement, and it aims to find ways to improve this through understanding brain chemicals and testing new treatments.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UTAH STATE UNIVERSITY (nih funded) |
| Locations | 1 site (LOGAN, UNITED STATES) |
| Trial ID | NIH-10437525 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how movement disorders like Parkinson's Disease affect the ability to estimate and reproduce time intervals, which is crucial for planning and executing movements. Using mouse models, the study will explore the neurobiological mechanisms behind these timing deficits, particularly the role of arousal and the neurotransmitter orexin. The researchers will also assess potential pharmacological treatments to improve motor timing. By enhancing our understanding of these processes, the research aims to inform future clinical strategies for treating cognitive and motor control deficits in patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's Disease or similar movement disorders who experience cognitive and motor timing deficits.
Not a fit: Patients without movement disorders or those who do not exhibit cognitive deficits related to timing may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that improve motor control and cognitive function in patients with movement disorders.
How similar studies have performed: Other research has shown promise in understanding timing deficits in movement disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
LOGAN, UNITED STATES
- UTAH STATE UNIVERSITY — LOGAN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BUHUSI, CATALIN V. — UTAH STATE UNIVERSITY
- Study coordinator: BUHUSI, CATALIN V.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.