Investigating therapies for heart failure with mid-range ejection fraction
Effectiveness of Therapies for Heart Failure with Mid-Range Ejection Fraction
['FUNDING_OTHER'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11192968
This study is looking at how well different treatments work for people with heart failure and a specific heart function level, to help doctors make better decisions about care.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11192968 on ClinicalTrials.gov |
What this research studies
This research aims to evaluate the effectiveness of various therapies for patients suffering from heart failure with mid-range ejection fraction (HFmrEF). By building the largest echocardiography registry in the world, the study will gather real-world data to compare treatment outcomes for different medications. The researchers will apply advanced statistical methods to analyze how treatment decisions vary based on specific thresholds of left ventricular ejection fraction (LVEF). This approach seeks to clarify the ambiguous guidelines currently surrounding HFmrEF and provide clearer recommendations for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with heart failure with mid-range ejection fraction who are receiving or considering guideline-directed medical therapies.
Not a fit: Patients with heart failure with reduced ejection fraction or those without heart failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that significantly reduce mortality rates for patients with heart failure with mid-range ejection fraction.
How similar studies have performed: Previous research has shown success in using real-world data to improve treatment guidelines for other heart failure conditions, suggesting this approach may also yield valuable insights for HFmrEF.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WASFY, JASON HARMON — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: WASFY, JASON HARMON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cardiac Diseases, Cardiac Disorders