Investigating therapies for heart failure with mid-range ejection fraction
Official title: Effectiveness of Therapies for Heart Failure with Mid-Range Ejection Fraction
Funded at Massachusetts General Hospital · NIH-11192968 · Data updated 2026-11-12
This study is looking at how well different treatments work for people with heart failure and a specific heart function level, to help doctors make better decisions about care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 24, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $777,674 |
| NIH project number | 1R56HL171144-01A1 |
| Project ID | NIH-11192968 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with heart failure with mid-range ejection fraction who are receiving or considering guideline-directed medical therapies.
✕Less likely to help
Patients with heart failure with reduced ejection fraction or those without heart failure may not benefit from this research.
What this research studies
This research aims to evaluate the effectiveness of various therapies for patients suffering from heart failure with mid-range ejection fraction (HFmrEF). By building the largest echocardiography registry in the world, the study will gather real-world data to compare treatment outcomes for different medications. The researchers will apply advanced statistical methods to analyze how treatment decisions vary based on specific thresholds of left ventricular ejection fraction (LVEF). This approach seeks to clarify the ambiguous guidelines currently surrounding HFmrEF and provide clearer recommendations for treatment.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that significantly reduce mortality rates for patients with heart failure with mid-range ejection fraction.
How similar studies have gone: Previous research has shown success in using real-world data to improve treatment guidelines for other heart failure conditions, suggesting this approach may also yield valuable insights for HFmrEF.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Wasfy, Jason Harmon — Massachusetts General Hospital
- Study coordinator: Wasfy, Jason Harmon
Related research
Other NIH-funded projects on the same topics.
-
AI-supported heart failure diagnosis and management in Rwanda
Aiming to help people with suspected heart failure in Rwanda get faster, more accurate diagnoses and better care using AI-guided ultrasound and care protocols.
-
AI-assisted heart failure diagnosis in Rwanda using focused ultrasound
An NIH-funded project will test whether AI-enhanced, easy-to-use heart ultrasound can help non-experts diagnose and manage heart failure in Rwanda.
-
HF endotypes in heart failure using ethical multi-modal AI and molecular data
A patient-friendly project that uses advanced AI and multiple kinds of health data to identify distinct heart failure subtypes that could guide personalized care.
-
Triple gene therapy approach to heal the heart after a heart attack
A new therapy combines three genetic approaches delivered by a virus to help the heart heal after a heart attack.
-
Digital-first heart failure care delivery in Uganda
A targeted program in Uganda tests a digital care plan to help people with heart failure manage their symptoms at home.
-
Digital-first heart failure care delivery in Uganda
A study to test digital self-care tools to help people with heart failure in Uganda manage symptoms and stay healthier.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.