Investigating therapies for Down Syndrome Regression Disorder
Official title: Mechanistic investigation of therapies for Down Syndrome Regression Disorder
Funded at University of Colorado Denver · NIH-11145996 · Data updated 2026-11-12
This study is looking into Down Syndrome Regression Disorder, which can cause serious challenges like losing the ability to communicate and difficulties with daily activities, and it aims to find out what causes these issues and how different treatments, like medications and immunotherapy, can help improve the lives of those affected.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $1,253,643 |
| NIH project number | 4R33HD109748-03 |
| Project ID | NIH-11145996 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Down syndrome who are experiencing symptoms of regression, such as loss of communication or aggressive behavior.
✕Less likely to help
Patients with Down syndrome who do not exhibit symptoms of regression or related neurological conditions may not benefit from this research.
What this research studies
This research focuses on understanding Down Syndrome Regression Disorder (DSRD), a condition affecting individuals with Down syndrome that leads to severe symptoms such as loss of communication, aggression, and inability to perform daily activities. The study aims to explore the underlying causes of DSRD and evaluate the effectiveness of various therapeutic approaches, including psychiatric medications and immunotherapy. By conducting a comprehensive clinical program, the research seeks to provide insights into the safety and efficacy of these treatments, potentially improving care for affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for individuals with Down Syndrome Regression Disorder, improving their quality of life.
How similar studies have gone: While there is ongoing research into therapies for Down syndrome and related conditions, the specific investigation of Down Syndrome Regression Disorder and its treatments is relatively novel.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Espinosa, Joaquin M. — University of Colorado Denver
- Study coordinator: Espinosa, Joaquin M.
Related research
Other NIH-funded projects on the same topics.
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Exploring how Down syndrome affects optic nerve health in kids
A study using a mouse model to understand why optic nerve problems are common in children with Down syndrome and how to prevent them.
-
Executive Function Enhancement for Young Children with Down Syndrome
A caregiver-guided program for kids with Down syndrome aged up to 11 to strengthen their thinking skills during early childhood.
-
Silencing an Extra Chromosome to Help Down Syndrome and Related Conditions
A patient-friendly plan to use a gene-based approach to quiet an extra chromosome in cells and a mouse model to reduce disease-related effects in Down syndrome and other chromosomal imbalance disorders.
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Infant Down Syndrome Brain and Behavior Study
A study of infants with Down syndrome to collect brain imaging and developmental data, creating a large, shared resource to understand how autism and other factors relate to development.
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DS-ARC: Smartphone-based cognitive check for people with Down syndrome at risk for Alzheimer’s
A smartphone-based cognitive test is being developed and tested for people with Down syndrome who may develop Alzheimer’s disease, to track changes quietly in daily life.
-
Immune and NGF factors in Alzheimer’s for adults with Down syndrome
This grant studies why people with Down syndrome develop Alzheimer’s disease by looking at immune signals and nerve growth factor problems.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.