Investigating the use of statins in patients with brain hemorrhage
StATins Use in intRacerebral hemorrhage patieNts (SATURN)
This study is looking to find out if people who have had a certain type of brain bleed should keep taking their cholesterol-lowering medication, called statins, or stop taking them, and it will help us understand how this choice affects their chances of having another brain bleed or heart problems over two years.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11088704 on NIH RePORTER |
What this research studies
This research aims to determine whether patients who have experienced a specific type of brain hemorrhage, known as lobar intracerebral hemorrhage (ICH), should continue or stop taking statins. The study will involve a multi-center, pragmatic, prospective, randomized clinical trial where participants will be assigned to either continue or discontinue their statin medication. Researchers will assess the impact of these decisions on the risk of recurrent brain hemorrhage and other serious cardiovascular events over a period of 24 months. The study will also evaluate long-term functional and cognitive outcomes for the participants.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have experienced lobar intracerebral hemorrhage and are currently taking statins.
Not a fit: Patients who have not experienced a lobar intracerebral hemorrhage or those not taking statins may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide critical insights into the safest management of statin therapy for patients at risk of recurrent brain hemorrhage.
How similar studies have performed: While the benefits of statins in reducing cardiovascular events are well established, this specific approach to managing statin therapy in ICH patients is novel and has not been extensively tested in prior studies.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Selim, Magdy H — Beth Israel Deaconess Medical Center
- Study coordinator: Selim, Magdy H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.