Investigating the use of statins in patients with brain hemorrhage
Official title: StATins Use in intRacerebral hemorrhage patieNts (SATURN)
Funded at Beth Israel Deaconess Medical Center · NIH-11088704 · Data updated 2026-11-12
This study is looking to find out if people who have had a certain type of brain bleed should keep taking their cholesterol-lowering medication, called statins, or stop taking them, and it will help us understand how this choice affects their chances of having another brain bleed or heart problems over two years.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2019 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $2,928,100 |
| NIH project number | 5U01NS102289-05 |
| Project ID | NIH-11088704 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who have experienced lobar intracerebral hemorrhage and are currently taking statins.
✕Less likely to help
Patients who have not experienced a lobar intracerebral hemorrhage or those not taking statins may not benefit from this research.
What this research studies
This research aims to determine whether patients who have experienced a specific type of brain hemorrhage, known as lobar intracerebral hemorrhage (ICH), should continue or stop taking statins. The study will involve a multi-center, pragmatic, prospective, randomized clinical trial where participants will be assigned to either continue or discontinue their statin medication. Researchers will assess the impact of these decisions on the risk of recurrent brain hemorrhage and other serious cardiovascular events over a period of 24 months. The study will also evaluate long-term functional and cognitive outcomes for the participants.
Why it matters
Potential benefit: If successful, this research could provide critical insights into the safest management of statin therapy for patients at risk of recurrent brain hemorrhage.
How similar studies have gone: While the benefits of statins in reducing cardiovascular events are well established, this specific approach to managing statin therapy in ICH patients is novel and has not been extensively tested in prior studies.
Where this research is happening
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Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Selim, Magdy H — Beth Israel Deaconess Medical Center
- Study coordinator: Selim, Magdy H
Related research
Other NIH-funded projects on the same topics.
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Anticoagulation in ICH Survivors with Atrial Fibrillation and Small Vessel Disease
This project looks at how to safely use blood-thinning medicines in people who survived a brain bleed and also have atrial fibrillation and small vessel disease.
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Statin use after lobar intracerebral hemorrhage
This trial compares continuing versus stopping statins in people who had a lobar intracerebral hemorrhage to see how that affects repeat brain bleeds, strokes, heart attacks, and recovery over two years.
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Statin use after lobar brain hemorrhage
This trial compares stopping versus continuing statin medicine in people who had a lobar brain bleed to learn effects on repeat bleeding and future heart or stroke events.
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Blocking red blood cell death after brain hemorrhage
A study at Yale is exploring whether stopping a specific kind of red blood cell death after a brain hemorrhage could improve recovery.
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Targeting HDAC3 to reduce brain damage after a brain bleed
This project will test whether blocking a protein called HDAC3 can reduce inflammation and improve recovery after an intracerebral hemorrhage (brain bleed).
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Silent brain injuries after brain bleed may predict dementia risk
A study using MRI and cognitive tests to see if hidden brain injuries after spontaneous intracerebral hemorrhage help forecast later cognitive decline.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.