Investigating the use of phage cocktails to combat antibiotic-resistant bacteria
Official title: Pharmacokinetics and Pharmacodynamics of Mechanistically Aware Phage Cocktails
Funded at State University of New York at Buffalo · NIH-10980990 · Data updated 2026-11-12
This study is exploring a new treatment using viruses called phages to help fight tough infections caused by antibiotic-resistant bacteria, specifically for patients dealing with Pseudomonas aeruginosa, and aims to find the best way to use these phages to make them work better than regular antibiotics.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | August 12, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $714,053 |
| NIH project number | 1R01AI177997-01A1 |
| Project ID | NIH-10980990 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with infections caused by extensively-drug resistant Pseudomonas aeruginosa.
✕Less likely to help
Patients with infections caused by bacteria that are not targeted by the specific phage cocktails being studied may not receive any benefit from this research.
What this research studies
This research focuses on developing and optimizing phage therapy, a promising treatment for infections caused by antibiotic-resistant bacteria, specifically targeting extensively-drug resistant Pseudomonas aeruginosa. The approach involves understanding how phages interact with bacteria and how their pharmacokinetics and pharmacodynamics can be tailored for effective treatment. By studying five specific phage therapeutics, the research aims to establish optimal dosing regimens that enhance their effectiveness against resistant infections. Patients may benefit from a new treatment option that could be more effective than traditional antibiotics.
Why it matters
Potential benefit: If successful, this research could provide a novel and effective treatment for patients suffering from infections caused by antibiotic-resistant bacteria.
How similar studies have gone: Previous research has shown promising results with phage therapy, indicating potential for success with similar approaches in treating antibiotic-resistant infections.
Where this research is happening
-
State University of New York at Buffalo
Amherst, United States Active
Researchers
- Principal investigator: Smith, Nicholas Michael — State University of New York at Buffalo
- Study coordinator: Smith, Nicholas Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.