Investigating the structures of toxic and infectious protein assemblies
Micro Electron Diffraction of Toxic and/or Infectious Macromolecular Nanoassemblies
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-10765275
This study is exploring the tricky structures of harmful proteins called amyloids to help find better ways to diagnose and treat diseases linked to them, using advanced imaging techniques and computer technology.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10765275 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the complex structures of toxic and infectious macromolecular assemblies, particularly amyloids, which are challenging to visualize using traditional methods. By employing advanced techniques like Micro Electron Diffraction (MicroED) and machine learning, the study aims to uncover detailed atomic structures that could lead to better diagnostics and therapeutics. Patients may benefit from improved understanding and potential treatments for diseases associated with amyloid structures, as the research seeks to fill critical gaps in our knowledge of these proteins. The approach combines experimental and computational tools to rapidly visualize and analyze these complex biological entities.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with conditions associated with amyloid diseases, such as Alzheimer's or other neurodegenerative disorders.
Not a fit: Patients with non-amyloid related conditions or those not affected by protein misfolding diseases may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in diagnosing and treating diseases related to amyloid structures.
How similar studies have performed: Other research has shown promise in using advanced imaging techniques to study protein structures, indicating that this approach could yield valuable insights.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RODRIGUEZ, JOSE ALFONSO — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: RODRIGUEZ, JOSE ALFONSO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.