Investigating the structures and dynamics of protein and protein-DNA complexes in health and disease
Official title: Structural and dynamic studies of protein and protein-nucleic acid assemblies in health and disease
Funded at Ohio State University · NIH-11010454 · Data updated 2026-11-12
This study is exploring the shapes and movements of important protein and DNA structures in our bodies to better understand how they work, which could help us find new ways to treat diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | June 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $597,573 |
| NIH project number | 1R35GM156238-01 |
| Project ID | NIH-11010454 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to protein misfolding or nucleic acid assembly, such as certain neurodegenerative diseases.
✕Less likely to help
Patients with conditions unrelated to protein or nucleic acid structures may not receive any benefit from this research.
What this research studies
This research focuses on understanding the three-dimensional structures and dynamic behaviors of large protein and protein-nucleic acid assemblies, which are crucial for various biological functions. By utilizing advanced techniques like multidimensional magic-angle spinning solid-state nuclear magnetic resonance and cryo-electron microscopy, the researchers aim to uncover the atomic-level details of these complex systems. This knowledge could lead to insights into how these assemblies function in health and disease, potentially informing new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of critical biological processes and lead to improved treatments for diseases associated with protein and nucleic acid dysfunction.
How similar studies have gone: Previous research has shown success in using advanced structural biology techniques to study protein complexes, indicating that this approach is promising and builds on established methodologies.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Jaroniec, Christopher P — Ohio State University
- Study coordinator: Jaroniec, Christopher P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.