Investigating the structure of glycosaminoglycans using electrical conductance techniques
Official title: Sequencing Glycosaminoglycans using Single Molecule Enzyme Conductance Fluctuations
Funded at Arizona State University-Tempe Campus · NIH-10766842 · Data updated 2026-11-12
This study is exploring a new way to understand important molecules called glycosaminoglycans (GAGs), which play a key role in blood clotting and inflammation, to help improve how we diagnose and treat related health conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $223,270 |
| NIH project number | 5R21GM148682-02 |
| Project ID | NIH-10766842 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to blood coagulation disorders or those who may benefit from anticoagulant therapies.
✕Less likely to help
Patients who do not have any blood coagulation disorders or related conditions may not receive direct benefits from this research.
What this research studies
This research focuses on understanding glycosaminoglycans (GAGs), which are important molecules involved in various biological processes such as blood coagulation and inflammation. The team aims to develop a novel method to sequence these complex polysaccharides by measuring fluctuations in electrical conductance as GAG lyases interact with them. This approach could provide insights into the structure and function of GAGs, which are crucial for their role as anticoagulants and biomarkers for diseases. By utilizing single-molecule techniques, the research seeks to overcome the challenges posed by traditional methods of analyzing GAG structures.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of conditions related to blood coagulation and other diseases linked to glycosaminoglycans.
How similar studies have gone: While the approach of using electrical conductance to analyze biomolecules is innovative, similar techniques have shown promise in other areas of molecular biology, indicating potential for success.
Where this research is happening
-
Arizona State University-Tempe Campus
Tempe, United States Active
Researchers
- Principal investigator: Wang, Xu — Arizona State University-Tempe Campus
- Study coordinator: Wang, Xu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.