Investigating the structure and function of the HIV-1 envelope protein
HIV-1 Env protein structure and function assessed by parallel smFRET and cryoET
This study is looking at a part of the HIV virus that helps it enter our cells, using special tools to see how it moves and changes shape, which could help scientists create better vaccines to fight the virus.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10865042 on NIH RePORTER |
What this research studies
This research focuses on the HIV-1 envelope protein (Env), which plays a crucial role in the virus's ability to enter human cells. By using advanced techniques like single-molecule Förster Resonance Energy Transfer (smFRET) and cryo-electron tomography (cryoET), the study aims to understand the dynamic behavior and structural states of Env on the virus surface. This knowledge could help in developing effective vaccines by revealing how Env interacts with antibodies and other cellular components during the infection process.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of HIV infection or those living with HIV who are interested in new vaccine developments.
Not a fit: Patients who are not at risk for HIV or those who are already receiving effective treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective vaccines against HIV, potentially reducing the incidence of AIDS.
How similar studies have performed: Previous research has shown promise in using similar structural biology techniques to understand viral proteins, indicating potential for success in this approach.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Mothes, Walther H — Yale University
- Study coordinator: Mothes, Walther H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.