Investigating the structure and function of proteins in cilia
Structural and functional studies of axonemal microtubule inner proteins (MIPs)
This study is looking at tiny structures called cilia that help our cells move and sense things, and it's trying to figure out how their special design keeps them working well, which could help people with diseases caused by cilia problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10912456 on NIH RePORTER |
What this research studies
This research focuses on understanding cilia, which are essential for cell movement and sensory functions. It explores the axoneme, the core structure of cilia, to determine how its unique architecture supports cellular motility. By using advanced techniques like cryo-electron microscopy, the study aims to uncover the molecular components and their roles in maintaining cilia function. Patients with ciliopathies, diseases caused by cilia dysfunction, may benefit from insights gained through this research.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with ciliopathies or related conditions that affect cilia function.
Not a fit: Patients without any cilia-related disorders or those not experiencing symptoms related to cilia dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases caused by cilia dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding cilia structure and function, indicating that this approach has potential for success.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Zhang, Rui — Washington University
- Study coordinator: Zhang, Rui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.