Investigating the structure and function of non-coding RNA
Official title: Structure and Function of Non-Coding RNA
Funded at University of Chicago · NIH-11057590 · Data updated 2026-11-12
This study is looking at tiny molecules called non-coding RNAs and how they work with proteins and small substances in our cells, to help us understand their role in keeping us healthy or contributing to diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | June 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $627,855 |
| NIH project number | 5R35GM149336-03 |
| Project ID | NIH-11057590 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to RNA dysfunction or diseases where ncRNAs play a significant role.
✕Less likely to help
Patients with conditions unrelated to RNA biology or those not affected by ncRNA-related mechanisms may not benefit from this research.
What this research studies
This research focuses on understanding non-coding RNAs (ncRNAs) and their interactions with proteins and small molecules. The team will use advanced biochemical and chemical tools to explore how these RNAs function within cells, particularly through their three-dimensional structures. By engineering specific proteins to assist in visualizing these structures, the research aims to uncover the mechanisms by which ncRNAs contribute to cellular processes in both health and disease.
Why it matters
Potential benefit: If successful, this research could lead to new insights into RNA biology that may improve treatments for various diseases.
How similar studies have gone: Previous research has shown promising results in understanding RNA structures and functions, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Piccirilli, Joseph Anthony — University of Chicago
- Study coordinator: Piccirilli, Joseph Anthony
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.