Investigating the structure and function of kainate-type glutamate receptors in the brain
Structure and Function of native kainate-type ionotropic glutamate receptor complexes
This study is looking at how certain brain receptors work and how they might be linked to conditions like Alzheimer's and autism, with the hope of finding new ways to help improve learning and memory.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10902092 on NIH RePORTER |
What this research studies
This research focuses on understanding how kainate-type ionotropic glutamate receptors (KARs) function in the brain and their role in various neurological disorders. By examining the structure and interactions of these receptors, the study aims to uncover their involvement in excitatory synaptic transmission, which is crucial for learning and memory. The research employs advanced techniques like cryo-electron microscopy to visualize these receptors at a molecular level, potentially revealing new drug targets for conditions such as Alzheimer's disease and autism spectrum disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease, autism spectrum disorders, or other related brain disorders.
Not a fit: Patients with conditions unrelated to glutamate signaling or those not diagnosed with the specified neurological disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neurological disorders linked to dysfunctional glutamate signaling.
How similar studies have performed: Previous research has shown promise in targeting ionotropic glutamate receptors for therapeutic interventions, indicating that this approach could yield significant insights.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Tajima, Nami — Case Western Reserve University
- Study coordinator: Tajima, Nami
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.