Investigating the structure and dynamics of membrane proteins using advanced spectroscopy techniques.
Official title: EPR Spectroscopic Studies of Membrane Proteins
Funded at Miami University Oxford · NIH-11019680 · Data updated 2026-11-12
This study is all about learning how important proteins in our cell membranes work, using special techniques to get a clearer picture of them in a setting that mimics real cell membranes, so we can better understand their roles in our bodies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Miami University Oxford NIH-funded |
| Lab location | 1 site (Oxford, United States) |
| Project start | May 1, 2018 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $349,560 |
| NIH project number | 5R35GM126935-07 |
| Project ID | NIH-11019680 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to membrane protein dysfunction, such as certain cancers or cardiac diseases.
✕Less likely to help
Patients with conditions unrelated to membrane proteins or those who do not have a specific biological issue related to membrane function may not benefit from this research.
What this research studies
This research focuses on understanding the structural and dynamic properties of integral membrane proteins, which are crucial for various biological functions. The Lorigan lab employs cutting-edge pulsed EPR spectroscopic techniques combined with membrane solubilizing polymers to study these proteins in a lipid bilayer environment, closely resembling natural cell membranes. This approach aims to overcome challenges faced when studying membrane proteins in less representative environments, such as micelles. By improving sample preparation and utilizing advanced instrumentation, the lab collaborates with other researchers to generate high-quality data that enhances our understanding of membrane protein behavior.
Why it matters
Potential benefit: If successful, this research could lead to better insights into membrane protein functions, potentially aiding in the development of new therapies for diseases related to these proteins.
How similar studies have gone: While the specific techniques used in this research are innovative, similar approaches in studying membrane proteins have shown promise in other research settings.
Where this research is happening
-
Miami University Oxford
Oxford, United States Active
Researchers
- Principal investigator: Lorigan, Gary a — Miami University Oxford
- Study coordinator: Lorigan, Gary a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.