Investigating the structure and dynamics of chromatin in cells and lab settings
Structural biology of chromatin in vitro and in cells
This study is looking at how changes to the DNA packaging in our cells can affect how our genes work, using special lab techniques to learn more about these processes both in test tubes and in living cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10869977 on NIH RePORTER |
What this research studies
This research focuses on developing advanced methods to study chromatin, the complex of DNA and proteins that packages genetic information in cells. By using solid-state nuclear magnetic resonance (NMR) spectroscopy combined with chemical biology tools, the research aims to understand how modifications like acetylation and methylation affect chromatin structure and function. The goal is to explore these processes both in vitro (in the lab) and within living cells, providing insights into how chromatin dynamics influence gene expression and cellular behavior.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to chromatin alterations, such as certain types of cancer or genetic disorders.
Not a fit: Patients with conditions unrelated to chromatin structure or function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases related to chromatin dysfunction, including various cancers.
How similar studies have performed: Previous research has shown success in understanding chromatin dynamics using similar methodologies, indicating a promising avenue for further exploration.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Debelouchina, Galia — University of California, San Diego
- Study coordinator: Debelouchina, Galia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.