Investigating the spatial arrangement of cells in tissues using advanced imaging and transcriptomic techniques
DMS/NIGMS 1: Topological Study on Histological Images and Spatial Transcriptomics
['FUNDING_R01'] · STATE UNIVERSITY NEW YORK STONY BROOK · NIH-10896999
This study is exploring how different types of cells in cancer and brain tissues are organized and work together, which could help us understand more about health and disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STATE UNIVERSITY NEW YORK STONY BROOK (nih funded) |
| Locations | 1 site (STONY BROOK, UNITED STATES) |
| Trial ID | NIH-10896999 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the tissue microenvironment in cancer and neuroscience by combining high-resolution transcriptomic profiling with histological image analysis. It aims to create a comprehensive mapping of how different cells, such as neurons, glial cells, and immune cells, are spatially arranged within tissues. By utilizing advanced topological data analysis, the project seeks to integrate cellular gene expression profiles with their spatial context, providing a richer understanding of tissue function. This innovative approach could lead to new insights into how cellular arrangements affect health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to cancer or neurological disorders who may benefit from insights into the tissue microenvironment.
Not a fit: Patients with conditions unrelated to cancer or neurological disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of tissue function and disease mechanisms, potentially leading to improved diagnostic and therapeutic strategies.
How similar studies have performed: Other research has shown promising results in integrating transcriptomic and imaging data, indicating that this approach has potential for significant advancements in understanding tissue microenvironments.
Where this research is happening
STONY BROOK, UNITED STATES
- STATE UNIVERSITY NEW YORK STONY BROOK — STONY BROOK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, CHAO — STATE UNIVERSITY NEW YORK STONY BROOK
- Study coordinator: CHEN, CHAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.