Investigating the safety of migraine treatments in patients with a history of stroke
Safety of Anti-CGRP Migraine Therapeutics in Ischemic Stroke
This study is looking at new migraine treatments that block a molecule important for blood flow in the brain to see if they might raise the risk of stroke or other brain issues, especially for people who have migraines and a history of stroke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11090485 on NIH RePORTER |
What this research studies
This research focuses on understanding the safety of new migraine treatments that block a molecule called CGRP, which is important for blood flow in the brain. The study aims to determine if these treatments could increase the risk of stroke or other cerebrovascular events in patients who suffer from migraines. By using animal models, the researchers will assess how these treatments affect blood flow and the risk of brain injury during ischemic events. The goal is to refine treatment recommendations for migraine patients who may also have a history of stroke.
Who could benefit from this research
Good fit: Ideal candidates for this research are migraine sufferers who have experienced ischemic strokes or transient ischemic attacks.
Not a fit: Patients who do not have a history of migraines or cerebrovascular events may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could help identify safer migraine treatment options for patients with a history of ischemic stroke.
How similar studies have performed: Previous research has indicated potential risks associated with CGRP antagonism in animal models, suggesting that this area of investigation is critical and may lead to significant findings.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Ayata, Cenk — Massachusetts General Hospital
- Study coordinator: Ayata, Cenk
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.