Investigating the safety and immune effects of xenon gas in healthy individuals
Official title: Phase 1 Trial to Assess Safety and Immune Effects of Xenon Gas in Healthy Human Subjects
Funded at General Biophysics, LLC · NIH-10922789 · Data updated 2026-11-12
This study is looking at how breathing in xenon gas affects the immune system and brain health in healthy people, with the hope that it could help us understand and develop new treatments for Alzheimer's disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | General Biophysics, LLC NIH-funded |
| Lab location | 1 site (Wayland, United States) |
| Project start | October 1, 2021 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $1,181,555 |
| NIH project number | 5R42AG073059-03 |
| Project ID | NIH-10922789 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are healthy adults who do not have any neurodegenerative conditions.
✕Less likely to help
Patients with existing neurodegenerative diseases or significant health issues may not benefit from this research.
What this research studies
This research aims to evaluate the safety and immune effects of inhaling xenon gas in healthy volunteers. Participants will be exposed to xenon for varying durations, allowing researchers to assess how this gas interacts with the immune system and its potential implications for neurodegenerative diseases like Alzheimer's. The study focuses on understanding the role of microglia, a type of brain cell, in maintaining brain health and how xenon might influence their function. By examining these effects, the research seeks to lay the groundwork for future treatments targeting Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating Alzheimer's disease by modulating immune responses in the brain.
How similar studies have gone: While the use of xenon gas in this context is novel, similar approaches targeting microglial function have shown promise in preliminary studies.
Where this research is happening
-
General Biophysics, LLC
Wayland, United States Active
Researchers
- Principal investigator: Ilin, Ilya — General Biophysics, LLC
- Study coordinator: Ilin, Ilya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.