Investigating the roles of YAP and TAZ in melanoma progression
The shared and distinct cistromes of YAP and TAZ in melanoma
This study is looking at how two proteins, YAP and TAZ, play a role in the growth and spread of melanoma, a type of skin cancer, to help find better ways to treat it.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11035359 on NIH RePORTER |
What this research studies
This research focuses on understanding how two proteins, YAP and TAZ, contribute to the progression and spread of melanoma, a serious form of skin cancer. The researchers aim to identify the unique and shared functions of these proteins in cancer cells, particularly how they affect cell growth and movement. By conducting detailed genetic analyses, they will explore how YAP and TAZ interact with other factors to influence cancer behavior. This could lead to new insights into melanoma treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with melanoma, particularly those with advanced or metastatic disease.
Not a fit: Patients with non-melanoma skin cancers or early-stage melanoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for treating melanoma, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown that targeting specific molecular pathways in cancer can lead to significant advancements in treatment, suggesting potential success for this approach.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Lang, Deborah — Boston University Medical Campus
- Study coordinator: Lang, Deborah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.