Investigating the roles of SYK and ZAP70 kinases in B-cell development and malignancies
SYK and ZAP70 kinases in lymphocyte selection
This study is looking at how certain proteins in our cells help choose which B-cells, important for fighting infections, are kept or removed, especially those that could cause problems like autoimmune diseases or leukemia, and it's using mice to learn more about this process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11014952 on NIH RePORTER |
What this research studies
This research focuses on understanding how SYK and ZAP70 kinases influence the selection process of B-cells, which are crucial for the immune response. By studying these kinases, the research aims to uncover mechanisms that lead to the elimination of autoreactive and pre-malignant B-cell clones. The approach involves genetic mouse models to observe the effects of these kinases on B-cell development and the onset of malignancies like acute B-lymphocytic leukemia. The findings could provide insights into how aberrant expression of these kinases contributes to autoimmune diseases and B-cell malignancies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with B-cell malignancies such as acute B-lymphocytic leukemia or those with autoimmune conditions.
Not a fit: Patients with non-B-cell related malignancies or autoimmune diseases not involving B-cells may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating B-cell malignancies and autoimmune diseases.
How similar studies have performed: Previous research has shown that targeting similar pathways in B-cell development has led to significant advancements in understanding and treating B-cell malignancies.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Müschen, Markus — Yale University
- Study coordinator: Müschen, Markus
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.