Investigating the roles of specific proteins and RNA modifications in COVID-19
Official title: Biological Reagents and Infection Core
Funded at Ohio State University · NIH-11072969 · Data updated 2026-11-12
This study is looking at how certain proteins and RNA changes in the body affect how we fight off COVID-19, and it hopes to find new ways to improve treatments for patients by testing these ideas in animals.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | April 10, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $429,217 |
| NIH project number | 5P01AI175399-02 |
| Project ID | NIH-11072969 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals who have been infected with SARS-CoV-2 or are at risk of severe COVID-19 outcomes.
✕Less likely to help
Patients who have not been infected with SARS-CoV-2 or those with unrelated health conditions may not receive direct benefits from this research.
What this research studies
This research focuses on understanding how caspase-4/11 proteins and RNA epigenetic modifications affect the body's response to SARS-CoV-2, the virus responsible for COVID-19. By studying these factors in various organs such as the lungs, brain, blood, and heart, the research aims to uncover their roles in both innate and adaptive immunity. The team will utilize animal models to conduct experiments that could lead to the development of new therapeutics targeting these mechanisms. Patients may benefit from improved treatments based on the findings of this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies that enhance the immune response against COVID-19.
How similar studies have gone: Other research has shown promise in targeting immune responses to viral infections, suggesting that this approach could yield significant insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Li, Jianrong — Ohio State University
- Study coordinator: Li, Jianrong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.