Investigating the roles of Shroom3 in kidney health and disease
Dichotomous roles of Shroom3 in Tubular cells and Podocytes in native and allograft kidneys
This study is looking at how a gene called Shroom3 impacts kidney health and disease, especially for people with chronic kidney disease, by analyzing kidney samples to find out how it affects kidney damage and function, which could help develop new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10667453 on NIH RePORTER |
What this research studies
This research focuses on understanding how the Shroom3 gene affects kidney function and disease, particularly in chronic kidney disease (CKD). By examining kidney tissue samples from both native and transplanted kidneys, the study aims to uncover the mechanisms by which Shroom3 influences kidney fibrosis and overall renal health. The researchers will utilize advanced genetic techniques and animal models to explore the contrasting roles of Shroom3 in different kidney cell types, which could lead to new therapeutic strategies for CKD.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing chronic kidney disease or related kidney disorders.
Not a fit: Patients with acute kidney injury or those without chronic kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments that improve kidney function and reduce complications for patients with chronic kidney disease.
How similar studies have performed: Previous studies have shown promising results in understanding the genetic factors influencing kidney disease, suggesting that this research could build on established findings.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Menon, Madhav C — Yale University
- Study coordinator: Menon, Madhav C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.