Investigating the roles of Nell-1 in bone and brain development
Dual roles of Nell-1 in craniofacial bones and brain through interaction with Cntnap4
This study is looking at how a protein called Nell-1 helps with both bone growth in the face and brain function, especially how it works with another protein important for brain communication, to see if problems with this interaction might cause bone issues and behaviors linked to autism.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10892705 on NIH RePORTER |
What this research studies
This research explores the dual functions of a protein called Nell-1 in both craniofacial bone development and brain function. It focuses on how Nell-1 interacts with another protein, Cntnap4, which is important for neural communication. By studying genetically modified mice, the research aims to understand how disruptions in this interaction may lead to bone defects and behaviors associated with autism spectrum disorder. The findings could provide insights into the biological mechanisms underlying these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with autism spectrum disorder or related craniofacial conditions.
Not a fit: Patients without craniofacial abnormalities or autism spectrum disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for conditions related to craniofacial abnormalities and autism spectrum disorders.
How similar studies have performed: Previous research has shown promising results in understanding the roles of similar proteins in craniofacial and neurological development, suggesting potential for success in this area.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Soo, Chia — University of California Los Angeles
- Study coordinator: Soo, Chia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.