Investigating the roles of glycoRNAs in the immune response
Official title: Innate immune roles of glycoRNA
Funded at University of Connecticut Sch of Med/dnt · NIH-10897453 · Data updated 2026-11-12
This study is looking at special molecules called glycoRNAs that are found on immune cells, to see how they change when the body fights off infections like Salmonella and Herpes Simplex Virus, which could help us understand how our immune system works and how germs affect our cells.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $45,122 |
| NIH project number | 1F31AI178967-01A1 |
| Project ID | NIH-10897453 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve immune responses to infections.
✕Less likely to help
Patients with stable, non-infectious conditions may not receive any benefit from this research.
What this research studies
This research focuses on glycoRNAs, which are newly identified biopolymers made up of small non-coding RNAs and glycans that are found on the surface of mammalian cells. The study aims to understand how these glycoRNAs change in response to infections by pathogens like Salmonella and Herpes Simplex Virus. By using advanced techniques such as flow cytometry and RNA sequencing, researchers will analyze the expression of glycoRNAs in immune cells during infection. This could provide insights into the immune response and how pathogens manipulate host cell surfaces.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune responses against infections.
How similar studies have gone: While the specific role of glycoRNAs is novel, similar research on RNA and immune responses has shown promising results in understanding pathogen interactions.
Where this research is happening
-
University of Connecticut Sch of Med/dnt
Farmington, United States Active
Researchers
- Principal investigator: Graziano, Vincent Robert — University of Connecticut Sch of Med/dnt
- Study coordinator: Graziano, Vincent Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.