Investigating the roles of GABAA receptor subunits in brain function
GABAA RECEPTOR POPULATIONS IN HIPPOCAMPUS AND THALAMUS
This study is looking at how certain brain receptors work in areas important for mood and memory, using specially modified mice to help find out how they might lead to better treatments for depression.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11031288 on NIH RePORTER |
What this research studies
This research focuses on understanding the different types of GABAA receptors in the brain, particularly in the hippocampus and thalamus, which are crucial for regulating inhibition in the central nervous system. By creating genetically modified mouse models, the researchers aim to differentiate between the roles of specific receptor subunits, particularly the δ and γ2 subunits, in mental functions and their implications for developing new antidepressant therapies. The study will utilize advanced techniques to assess how these receptors contribute to brain activity and behavior, potentially leading to better-targeted treatments for mood disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from affective disorders, such as depression or anxiety, who may benefit from new treatment options.
Not a fit: Patients who do not have affective disorders or those who are not responsive to GABAA receptor-targeting treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective antidepressant medications that specifically target the underlying mechanisms of mood disorders.
How similar studies have performed: Previous research has shown promise in targeting specific GABAA receptor subunits for therapeutic effects, indicating that this approach could yield significant advancements in treatment.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Mennerick, Steven J — Washington University
- Study coordinator: Mennerick, Steven J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.