Investigating the role of zinc protoporphyrin in brain damage after bleeding in the brain
Official title: Endogenous zinc protoporphyrin in intracerebral hemorrhage
Funded at State University New York Stony Brook · NIH-11048804 · Data updated 2026-11-12
This study is looking at how a substance called zinc protoporphyrin (ZnPP) affects brain damage after a type of bleeding in the brain, hoping to find new ways to help people recover better from this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $537,508 |
| NIH project number | 1R01NS136494-01A1 |
| Project ID | NIH-11048804 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced an intracerebral hemorrhage and are at risk of subsequent brain damage.
✕Less likely to help
Patients who have not experienced an intracerebral hemorrhage or those with other unrelated neurological conditions may not benefit from this research.
What this research studies
This research focuses on understanding how zinc protoporphyrin (ZnPP), a compound formed in the brain after an intracerebral hemorrhage (ICH), contributes to brain damage. The study aims to identify the conditions that lead to the production of ZnPP and its mechanisms of neurotoxicity. By exploring the relationship between ICH, local tissue hypoxia, and ZnPP formation, the researchers hope to uncover new therapeutic targets that could mitigate brain injury. Patients may benefit from insights that could lead to improved treatments for ICH-related brain damage.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that significantly reduce brain damage and improve recovery outcomes for patients who suffer from intracerebral hemorrhage.
How similar studies have gone: While the specific approach of targeting ZnPP in ICH is novel, similar research has shown that addressing biochemical pathways involved in brain injury can lead to meaningful advancements in treatment.
Where this research is happening
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State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Liu, Ke Jian — State University New York Stony Brook
- Study coordinator: Liu, Ke Jian
Related research
Other NIH-funded projects on the same topics.
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Anticoagulation in ICH Survivors with Atrial Fibrillation and Small Vessel Disease
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Statin use after lobar intracerebral hemorrhage
This trial compares continuing versus stopping statins in people who had a lobar intracerebral hemorrhage to see how that affects repeat brain bleeds, strokes, heart attacks, and recovery over two years.
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Statin use after lobar brain hemorrhage
This trial compares stopping versus continuing statin medicine in people who had a lobar brain bleed to learn effects on repeat bleeding and future heart or stroke events.
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Blocking red blood cell death after brain hemorrhage
A study at Yale is exploring whether stopping a specific kind of red blood cell death after a brain hemorrhage could improve recovery.
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Targeting HDAC3 to reduce brain damage after a brain bleed
This project will test whether blocking a protein called HDAC3 can reduce inflammation and improve recovery after an intracerebral hemorrhage (brain bleed).
-
Silent brain injuries after brain bleed may predict dementia risk
A study using MRI and cognitive tests to see if hidden brain injuries after spontaneous intracerebral hemorrhage help forecast later cognitive decline.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.