Investigating the role of YAP1 in blood vessel health and blood pressure
Official title: YAP1, neointima formation, and blood pressure regulation
Funded at University of Toledo Health Sci Campus · NIH-10994137 · Data updated 2026-11-12
This study is looking at how a protein called YAP1 affects the cells that help keep our blood vessels healthy, especially in conditions like high blood pressure and artery hardening, to find new ways to treat these issues and improve health for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Toledo Health Sci Campus NIH-funded |
| Lab location | 1 site (Toledo, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $249,000 |
| NIH project number | 5R00HL153896-05 |
| Project ID | NIH-10994137 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of vascular diseases, such as atherosclerosis or hypertension.
✕Less likely to help
Patients with non-vascular related health issues or those without any history of vascular diseases may not benefit from this research.
What this research studies
This research focuses on understanding how a protein called YAP1 affects the behavior of vascular smooth muscle cells (VSMCs), which are crucial for maintaining healthy blood vessels. The study aims to explore how YAP1 influences VSMC growth and contraction, particularly in conditions like atherosclerosis and hypertension. By examining these processes, the researchers hope to uncover new therapeutic strategies for vascular diseases that can lead to better patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions like high blood pressure and vascular diseases, improving patient health and quality of life.
How similar studies have gone: Previous research has shown promising results in understanding the role of YAP1 in vascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Toledo Health Sci Campus
Toledo, United States Active
Researchers
- Principal investigator: Osman, Islam — University of Toledo Health Sci Campus
- Study coordinator: Osman, Islam
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.