Investigating the role of Y chromosome genes in diseases and cancers.
BLRD Research Career Scientist Award Application
This study is looking at how certain genes on the Y chromosome, like the SRY gene, might play a role in diseases and cancers that affect men and women differently, and it aims to help patients by finding better treatments based on these genetic insights.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Affairs Med Ctr San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11042123 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific genes on the Y chromosome, particularly the SRY gene and the proto-oncogene TSPY, contribute to various diseases and cancers that show differences between sexes. Using advanced transgenic mouse models, the research employs molecular genetics and genomics strategies to explore these contributions. Patients may benefit from insights gained into the genetic factors influencing their conditions, potentially leading to more targeted therapies. The research also utilizes next-generation sequencing technologies to analyze genetic data comprehensively.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with sexually dimorphic diseases or cancers that may be influenced by genetic factors on the Y chromosome.
Not a fit: Patients with conditions unrelated to Y chromosome genetics or those not affected by sexually dimorphic diseases may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for diseases influenced by Y chromosome genes.
How similar studies have performed: Previous research has shown success in understanding the role of sex chromosomes in various diseases, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
San Francisco, United States
- Veterans Affairs Med Ctr San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Lau, Yun-Fai Chris — Veterans Affairs Med Ctr San Francisco
- Study coordinator: Lau, Yun-Fai Chris
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.