Investigating the role of XAF1 in cancer development and cell death
XAF1 IN P53 SIGNALING, APOPTOSIS AND TUMOR SUPPRESSION
This study is looking at how two gene changes might work together in kids from Brazil who are at risk for a type of cancer called adrenocortical carcinoma, to help us understand why some kids with these changes get cancer while others don’t, which could lead to better ways to prevent and treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11030732 on NIH RePORTER |
What this research studies
This research focuses on understanding how a specific mutation in the XAF1 gene interacts with another mutation in the p53 gene, particularly in children from Brazil who are at risk for adrenocortical carcinoma. The study will utilize advanced genetic models to explore the role of XAF1 in promoting cell death (apoptosis) and preventing tumor growth. By examining these genetic interactions, the research aims to uncover why some carriers of these mutations develop cancer while others do not, potentially leading to new insights into cancer prevention and treatment.
Who could benefit from this research
Good fit: Ideal candidates for participation are children from southern Brazil who are carriers of the TP53-R337H mutation or have a family history of adrenocortical carcinoma.
Not a fit: Patients who do not carry the TP53-R337H mutation or are not at risk for adrenocortical carcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for identifying and managing cancer risk in children with specific genetic mutations.
How similar studies have performed: Previous research has shown promising results in understanding the role of genetic mutations in cancer, making this approach both relevant and potentially impactful.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Zambetti, Gerard Paul — St. Jude Children's Research Hospital
- Study coordinator: Zambetti, Gerard Paul
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.