Investigating the role of vitamin D in calcium regulation and parathyroid hormone secretion in older adults
Official title: Vitamin D and beta-amyloid signaling in hyperparathyroidism
Funded at University of California, San Francisco · NIH-10668177 · Data updated 2026-11-12
This study is looking at how not getting enough vitamin D affects calcium levels and hormone release in older adults, especially those with a condition called hyperparathyroidism, to find ways to help improve their bone health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | April 15, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $2,270,616 |
| NIH project number | 1RF1AG075742-01A1 |
| Project ID | NIH-10668177 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing vitamin D deficiency or diagnosed with hyperparathyroidism.
✕Less likely to help
Patients who are not elderly or do not have issues related to vitamin D deficiency or hyperparathyroidism may not benefit from this research.
What this research studies
This research focuses on understanding how vitamin D deficiency affects calcium balance and hormone secretion in older adults, particularly those with hyperparathyroidism. It aims to explore the mechanisms by which vitamin D interacts with parathyroid glands and influences the secretion of parathyroid hormone, which is crucial for maintaining bone health. By studying these interactions, the research seeks to identify potential therapeutic targets that could improve health outcomes for the elderly suffering from vitamin D deficiency and related conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for older adults with vitamin D deficiency and hyperparathyroidism, potentially reducing the risk of bone loss and fractures.
How similar studies have gone: Previous research has indicated the importance of vitamin D in calcium regulation, suggesting that this approach may yield valuable insights and potential breakthroughs.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Koh, James — University of California, San Francisco
- Study coordinator: Koh, James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.